APC Anti-Mouse F4/80 Antibody [CI:A3-1] (AGEL0568)

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SKU:
AGEL0568
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
CI:A3-1
Conjugation:
APC
Frequently bought together:

Description

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APC Anti-Mouse F4/80 Antibody [CI:A3-1]

The Mouse F4/80 Monoclonal Antibody (APC-conjugated, CI:A3-1, AGEL0568) is a powerful tool for researchers investigating macrophage populations in various biological systems. This antibody specifically targets the F4/80 antigen, a well-established marker for mouse macrophages, and is conjugated with APC for direct flow cytometry analysis. With its high specificity and sensitivity, this antibody is ideal for identifying and characterizing macrophages in tissues and cell cultures.Macrophages play integral roles in immune responses, tissue homeostasis, and inflammation, making them a key focus in immunology, infection, and cancer research.

The F4/80 antigen is widely used to distinguish macrophages from other immune cells and study their functions in different physiological and pathological conditions. By utilizing the Mouse F4/80 Monoclonal Antibody, researchers can gain invaluable insights into macrophage biology, immune modulation, and the pathogenesis of various diseases.

Product Title:APC Anti-Mouse F4/80 Antibody [CI:A3-1]
SKU:AGEL0568
Size:25µg, 100µg
Clone No:CI:A3-1
Synonyms:Adhesion G protein-coupled receptor E1;Adgre1;Cell surface glycoprotein F4/80;EGF-like module receptor 1;Adgre1;Emr1; Gpf480;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:APC Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q61549
Gene ID:13733
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:F4/80 is a 160 kD glycoprotein. It is characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80, also known as EMR1 or Ly71, has been widely used as a murine macrophage marker, which is expressed on the majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen (but not on the macrophages located in T cell areas of the spleen, lymph node and Peyer's patch), Kuffer cells, Langerhans cells, and bone marrow stromal cells. F4/80 has also been shown on a subset of dendritic cells. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for induction of CD8+ T cells-mediated peripheral tolerance.

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