GenieFluor 488 Anti-Mouse F4/80 Antibody [CI:A3-1] (AGEL0574)

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SKU:
AGEL0574
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
CI:A3-1
Conjugation:
AF 488
Frequently bought together:

Description

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GenieFluor 488 Anti-Mouse F4/80 Antibody [CI:A3-1]

The Mouse F4/80 Monoclonal Antibody (AF488 Conjugated, clone CI:A3-1, AGEL0574) offered by AssayGenie is a powerful tool for researchers studying macrophages in mouse tissues. This antibody specifically targets the F4/80 antigen, a well-known marker of mature mouse macrophages, making it an essential component for immunology and inflammation studies.Primarily conjugated with AF488 for fluorescence detection, this monoclonal antibody enables precise visualization of F4/80-positive cells in various tissues and cell types. It exhibits high specificity and sensitivity in immunofluorescence and flow cytometry applications. With clone CI:A3-1's proven performance and reliability, researchers can confidently analyze macrophage distribution, activation status, and function in experimental models.

Macrophages play pivotal roles in immune responses, tissue homeostasis, and pathogenesis of various diseases, including cancer, inflammation, and infection. By targeting the F4/80 antigen, researchers can gain deeper insights into macrophage biology and its contributions to different pathological conditions. Utilizing the Mouse F4/80 Monoclonal Antibody (AF488 Conjugated) from AssayGenie, scientists can advance their understanding of macrophage-related mechanisms and potentially discover novel therapeutic targets in immunology and disease research.

Product Title:GenieFluor 488 Anti-Mouse F4/80 Antibody [CI:A3-1]
SKU:AGEL0574
Size:25µg, 100µg
Clone No:CI:A3-1
Synonyms:Adhesion G protein-coupled receptor E1;Adgre1;Cell surface glycoprotein F4/80;EGF-like module receptor 1;Adgre1;Emr1; Gpf480;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Genie Fluor 488 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q61549
Gene ID:13733
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:F4/80 is a 160 kD glycoprotein. It is characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80, also known as EMR1 or Ly71, has been widely used as a murine macrophage marker, which is expressed on the majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen (but not on the macrophages located in T cell areas of the spleen, lymph node and Peyer's patch), Kuffer cells, Langerhans cells, and bone marrow stromal cells. F4/80 has also been shown on a subset of dendritic cells. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for induction of CD8+ T cells-mediated peripheral tolerance.

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