Mouse Exodus-2 Recombinant Protein (RPPB1133)

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SKU:
RPPB1133
Product type:
Recombinant Protein
Size:
10ug
Species:
Mouse
Target:
Exodus-2
Synonyms:
Ccl21a
Synonyms:
C-C motif chemokine 21a
Synonyms:
6Ckine
Synonyms:
Beta-chemokine exodus-2
Source:
Sf9 Insect cells
Uniprot:
P84444
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Description

Product Name:Mouse Exodus-2 Recombinant Protein
Product Code:RPPB1133
Size:10µg
Species:Mouse
Target:Exodus-2
Synonyms:Ccl21a, C-C motif chemokine 21a, 6Ckine, Beta-chemokine exodus-2, Small-inducible cytokine A21a,Thymus-derived chemotactic agent 4, TCA4, Ccl21a, Scya21, Scya21a, 6CKBAC2, 6Ckine, ALP,AW987545, CKb9, plt, Scya21b, SLC.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The  Exodus-2 solution (0.5mg/ml) contains  Phosphate-Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPSDGGGQD CCLKYSQKKI PYSIVRGYRK QEPSLGCPIP AILFSPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS PGCRKNRGTS KSGKKGKGSK GCKRTEQTQP SRGHHHHHH

Exodus-2 protein or CCL21 is a cytokine, part of the CC chemokines subgroup. Because of its 6 conserved residues of the cysteine amino acid (instead of the 4 residues we usually see in chemokines), the protein is also named 6Ckine and SLC (secondary lymphoid-tissue chemokine). The gene that codes for this protein is located on chromosome 9 in humans. The Exodus-2 is binding to the CCR7 receptor, which is a chemokine receptor located to the cell’s surface.

Exodus-2 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 119 amino acids (24-133aa) and having a molecular mass of 13.1kDa.Exodus-2 is fused to a 9 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.
UniProt Protein Details:
NCBI Summary:
UniProt Code:P84444
NCBI GenInfo Identifier:302488378
NCBI Gene ID:100504362
NCBI Accession:NP_001180596.1
UniProt Secondary Accession:P84444,O09002, O09006, Q3U1J2, Q91V84
UniProt Related Accession:P84444
Molecular Weight:14,558 Da
NCBI Full Name:predicted gene 1987
NCBI Synonym Full Names:predicted gene 1987
NCBI Official Symbol:Gm1987  
NCBI Official Synonym Symbols:100038965  
NCBI Protein Information:predicted gene 1987
UniProt Protein Name:C-C motif chemokine 21a
UniProt Synonym Protein Names:6Ckine; Beta-chemokine exodus-2; Small-inducible cytokine A21a; Thymus-derived chemotactic agent 4; TCA4
Protein Family:
UniProt Gene Name:Ccl21a  
UniProt Entry Name:
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