Mouse EBI3 Recombinant Protein (RPPB0159)
- SKU:
- RPPB0159
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Mouse
- Target:
- EBI3
- Synonyms:
- IL-27B
- IL27B
- IL 27-B
- EBI-3
- Source:
- Escherichia Coli
- Uniprot:
- O35228
Frequently bought together:
Description
| Product Name: | Mouse EBI3 Recombinant Protein |
| Product Code: | RPPB0159 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | EBI3 |
| Synonyms: | IL-27B, IL27B, IL 27-B, EBI-3, Interleukin-27 beta, IL-27 subunit beta, Epstein-Barr virus-induced gene 3 protein homolog, EBI3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | EBI3 was lyophilized from 10mM Sodium Citrate pH-3. |
| Solubility: | It is recommended to reconstitute the lyophilized EBI3 in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized EBI3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution EBI3 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MALVALSQPR VQCHASRYPV AVDCSWTPLQ APNSTRSTSF IATYRLGVAT QQQSQPCLQR SPQASRCTIP DVHLFSTVPY MLNVTAVHPG GASSSLLAFV AERIIKPDPP EGVRLRTAGQ RLQVLWHPPA SWPFPDIFSL KYRLRYRRRG ASHFRQVGPI EATTFTLRNS KPHAKYCIQV SAQDLTDYGK PSDWSLPGQV ESAPHKP |
EBI3 has an induced expression in B lymphocytes in reaction to Epstein-Barr virus infection. EBI3 encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form iIL-27. EBI3 drives rapid clonal expansion of naive cd4(+) t-cells. EBI3 strongly synergizes with IL-12 to activate IFN-gamma production of naive cd4(+) t-cells. EBI3 mediates its biologic effects through the cytokine receptor wsx-1/tccr.
EBI3 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 207 amino acids and having a molecular mass of 22.9kDa. The Murine EBI3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL27-beta: Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon- gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. Belongs to the type I cytokine receptor family. Type 3 subfamily.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 17 D|17 29.08 cMMolecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-27 receptor binding; protein bindingBiological Process: T cell proliferation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O35228 |
| NCBI GenInfo Identifier: | 47605771 |
| NCBI Gene ID: | 50498 |
| NCBI Accession: | O35228.1 |
| UniProt Secondary Accession: | O35228 |
| UniProt Related Accession: | O35228 |
| Molecular Weight: | 25,353 Da |
| NCBI Full Name: | Interleukin-27 subunit beta |
| NCBI Synonym Full Names: | Epstein-Barr virus induced gene 3 |
| NCBI Official Symbol: | Ebi3 |
| NCBI Official Synonym Symbols: | EBI-3; IL-27 |
| NCBI Protein Information: | interleukin-27 subunit beta |
| UniProt Protein Name: | Interleukin-27 subunit beta |
| UniProt Synonym Protein Names: | Epstein-Barr virus-induced gene 3 protein homolog |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Ebi3 |
| UniProt Entry Name: |
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