Coxsackievirus and adenovirus receptor homolog?CAR?? also known as CXADR, is a type I transmembrane glycoprotein that belongs to the CTX family of the Ig superfamily. CXADR has monomer subunit that interacts with LNX, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1. It also interacts with MPDZ and JAML. CXADR composed of of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. CXADR also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
Product Name:
Mouse CXADR/CAR Recombinant Protein (RPES2472)
Product Code:
RPES2472
Size:
20µg
Species:
Mouse
Expressed Host:
Human Cells
Synonyms:
Coxsackievirus and adenovirus receptor homolog,CAR,Cxadr,CVB3 BP,MCVADR
Accession:
P97792
Sequence:
Leu20-Gly237
Fusion tag:
C-AVI-His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Biotinylated Recombinant Mouse CXADR is produced by our Mammalian expression system and the target gene encoding Leu20-Gly237 is expressed with a Avi, 6Histag at the C-terminus.
Purity:
> 95% as determined by reducing SDS-PAGE.
Mol Mass:
26.7 kDa
AP Mol Mass:
30-40 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
