Mouse CNDP1 Recombinant Protein (RPPB1500)
- SKU:
- RPPB1500
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Mouse
- Target:
- CNDP1
- Synonyms:
- Beta-Ala-His dipeptidase
- CNDP dipeptidase 1
- Carnosinedipeptidase 1
- Source:
- Sf9 Insect cells
- Uniprot:
- Q8BUG2
Description
| Product Name: | Mouse CNDP1 Recombinant Protein |
| Product Code: | RPPB1500 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | CNDP1 |
| Synonyms: | Beta-Ala-His dipeptidase, CNDP dipeptidase 1, Carnosinedipeptidase 1. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | CNDP1 protein solution (0.25mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MFSSAHSGLL EKLFHYIDLH QDEFVQTLKE WVAIESDSVQ PVPRLRQKLFQMMALAADKL RNLGAGVESI DLGSQQMPDG QSLPIPPILL AELGSDPEKP TVCFYGHLDV QPAQKDDGWLTDPYTLTEVD GKLYGRGATD NKGPVLAWIN AVSTFRALQQ DLPVNIKLIL EGMEEAGSIA LEELVMREKDHFFSSVDYIV ISDNLWLSQR KPALTYGTRG NCYFTVEVKC RDQDFHSGTF GGILNEPMAD LVALLGSLVDSSGHILIPGI YDQMAPITEG EKTMYKNIDM DLEEYQNINQ VEKFLFDTKE ELLMHLWRYP SLSIHGIEGAFDEPGTKTVI PGRVLGKFSI RLVPTMSPSV VEKQVTQHLE AVFSKRNSFN KMAVSMVLGL HPWTANVNDTQYLAAQRTIK TVFGVNPDMI RDGSTIPIAK IFQAITQKSV MMLPLGAVDD GEHSQNEKIN RWNYIQGSKLFAAFFLELSK QHSGHQMPSS VYLEHHHHHH |
CNDP Dipeptidase 1, also known as CNDP1 is a member of the peptidase M20A family. CNDP1 Mannheim which is the shortest allelic form has been more common in the absence of nephropathy in addition to being associated with lower serum carnosinase levels. Furthermore, Carnosine inhibited the increased production of fibronectin as well as collagen type VI in podocytes and the increased production of TGF-beta in mesangial cells. Diabetic patients with the CNDP1 Mannheim variant are less at risk for nephropathy. In addition, on renal cells carnosine protects against the adverse effects of high glucose levels.
CNDP1 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 500 amino acids (1-492 a.a.) andhaving a molecular mass of 56.1kDa (Molecular size on SDS-PAGE will appear atapproximately 50-70kDa). CNDP1 is expressed with an 8 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CNDP1: a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region. [provided by RefSeq, Jul 2008]Protein type: Amino Acid Metabolism - histidine; EC 3.4.13.20; Other Amino Acids Metabolism - beta-alanine; Protease; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 18|18 E4Cellular Component: cytosolMolecular Function: dipeptidase activity; zinc ion bindingBiological Process: peptide catabolic process; proteolysis; regulation of cellular protein metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8BUG2 |
| NCBI GenInfo Identifier: | 157951637 |
| NCBI Gene ID: | 338403 |
| NCBI Accession: | NP_803233.2 |
| UniProt Secondary Accession: | Q8BUG2,Q80XP5 |
| UniProt Related Accession: | Q8BUG2 |
| Molecular Weight: | 55,090 Da |
| NCBI Full Name: | beta-Ala-His dipeptidase |
| NCBI Synonym Full Names: | carnosine dipeptidase 1 (metallopeptidase M20 family) |
| NCBI Official Symbol: | Cndp1 |
| NCBI Official Synonym Symbols: | Cn1; AI746433 |
| NCBI Protein Information: | beta-Ala-His dipeptidase |
| UniProt Protein Name: | Beta-Ala-His dipeptidase |
| UniProt Synonym Protein Names: | CNDP dipeptidase 1; Carnosine dipeptidase 1 |
| Protein Family: | Beta-Ala-His dipeptidase |
| UniProt Gene Name: | Cndp1 |
| UniProt Entry Name: |
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