Mouse CNDP1 Recombinant Protein (RPPB1500)

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SKU:
RPPB1500
Product type:
Recombinant Protein
Size:
10ug
Species:
Mouse
Target:
CNDP1
Synonyms:
Beta-Ala-His dipeptidase
Synonyms:
CNDP dipeptidase 1
Synonyms:
Carnosinedipeptidase 1
Source:
Sf9 Insect cells
Uniprot:
Q8BUG2
€0.00
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Description

Product Name:Mouse CNDP1 Recombinant Protein
Product Code:RPPB1500
Size:10µg
Species:Mouse
Target:CNDP1
Synonyms:Beta-Ala-His dipeptidase, CNDP dipeptidase 1, Carnosinedipeptidase 1.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CNDP1 protein solution (0.25mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MFSSAHSGLL EKLFHYIDLH QDEFVQTLKE WVAIESDSVQ PVPRLRQKLFQMMALAADKL RNLGAGVESI DLGSQQMPDG QSLPIPPILL AELGSDPEKP TVCFYGHLDV QPAQKDDGWLTDPYTLTEVD GKLYGRGATD NKGPVLAWIN AVSTFRALQQ DLPVNIKLIL EGMEEAGSIA LEELVMREKDHFFSSVDYIV ISDNLWLSQR KPALTYGTRG NCYFTVEVKC RDQDFHSGTF GGILNEPMAD LVALLGSLVDSSGHILIPGI YDQMAPITEG EKTMYKNIDM DLEEYQNINQ VEKFLFDTKE ELLMHLWRYP SLSIHGIEGAFDEPGTKTVI PGRVLGKFSI RLVPTMSPSV VEKQVTQHLE AVFSKRNSFN KMAVSMVLGL HPWTANVNDTQYLAAQRTIK TVFGVNPDMI RDGSTIPIAK IFQAITQKSV MMLPLGAVDD GEHSQNEKIN RWNYIQGSKLFAAFFLELSK QHSGHQMPSS VYLEHHHHHH

CNDP Dipeptidase 1, also known as CNDP1 is a member of the peptidase M20A family. CNDP1 Mannheim which is the shortest allelic form has been more common in the absence of nephropathy in addition to being associated with lower serum carnosinase levels. Furthermore, Carnosine inhibited the increased production of fibronectin as well as collagen type VI in podocytes and the increased production of TGF-beta in mesangial cells. Diabetic patients with the CNDP1 Mannheim variant are less at risk for nephropathy. In addition, on renal cells carnosine protects against the adverse effects of high glucose levels.

CNDP1 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 500 amino acids (1-492 a.a.) andhaving a molecular mass of 56.1kDa (Molecular size on SDS-PAGE will appear atapproximately 50-70kDa). CNDP1 is expressed with an 8 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:CNDP1: a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region. [provided by RefSeq, Jul 2008]Protein type: Amino Acid Metabolism - histidine; EC 3.4.13.20; Other Amino Acids Metabolism - beta-alanine; Protease; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 18|18 E4Cellular Component: cytosolMolecular Function: dipeptidase activity; zinc ion bindingBiological Process: peptide catabolic process; proteolysis; regulation of cellular protein metabolic process
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q8BUG2
NCBI GenInfo Identifier:157951637
NCBI Gene ID:338403
NCBI Accession:NP_803233.2
UniProt Secondary Accession:Q8BUG2,Q80XP5
UniProt Related Accession:Q8BUG2
Molecular Weight:55,090 Da
NCBI Full Name:beta-Ala-His dipeptidase
NCBI Synonym Full Names:carnosine dipeptidase 1 (metallopeptidase M20 family)
NCBI Official Symbol:Cndp1  
NCBI Official Synonym Symbols:Cn1; AI746433  
NCBI Protein Information:beta-Ala-His dipeptidase
UniProt Protein Name:Beta-Ala-His dipeptidase
UniProt Synonym Protein Names:CNDP dipeptidase 1; Carnosine dipeptidase 1
Protein Family:Beta-Ala-His dipeptidase
UniProt Gene Name:Cndp1  
UniProt Entry Name:
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