Biotin Anti-Mouse CD8a Antibody [53-6.7] (AGEL0379)

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SKU:
AGEL0379
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
53.6.7
Conjugation:
Biotin
Applications:
FC
Frequently bought together:

Description

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Biotin Anti-Mouse CD8a Antibody [53-6.7]

The Mouse CD8a Monoclonal Antibody (Biotin Conjugated) 53-6.7 (AGEL0379) is a highly specific research tool designed for the detection of CD8a, a cell surface marker associated with cytotoxic T cells. This monoclonal antibody, conjugated with biotin for enhanced detection capabilities, offers exceptional reactivity with mouse samples and is validated for various applications, including flow cytometry and immunohistochemistry.CD8a is a crucial marker for identifying cytotoxic T cells, which play a pivotal role in immune responses against infected or cancerous cells. By targeting CD8a, researchers can accurately analyze and characterize the presence and function of cytotoxic T cells in different experimental settings.

This antibody provides a reliable means of studying immune cell populations in immunology, infectious diseases, and cancer research, offering insights into the immune response mechanisms and potential therapeutic targets.By using the Mouse CD8a Monoclonal Antibody (Biotin Conjugated) 53-6.7 (AGEL0379), researchers can delve deeper into the intricate functions of CD8a-positive cells, paving the way for advancements in immunotherapy, vaccine development, and understanding immune-mediated diseases. Its specificity and reliability make it an indispensable tool for investigating the role of CD8a in immune surveillance, immune evasion, and immune-mediated pathologies.

Product Title:Biotin Anti-Mouse CD8a Antibody [53-6.7]
SKU:AGEL0379
Size:25µg, 100µg
Clone No:53-6.7
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Biotin Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P01731
Gene ID:12525
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

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