PerCP/Cyanine5.5 Anti-Mouse CD80 Antibody [16-10A1] (AGEL0538)

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SKU:
AGEL0538
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Armenian Hamster
Isotype:
IgG2a,k
Clone:
16-10A1
Conjugation:
PerCP/Cy5.5
Frequently bought together:

Description

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PerCP/Cyanine5.5 Anti-Mouse CD80 Antibody [16-10A1]

The Mouse CD80 Monoclonal Antibody (PERCP-Cyanine5.5 Conjugated, 16-10A1, AGEL0538) is a valuable tool for researchers studying the CD80 protein, a key immune checkpoint molecule involved in co-stimulatory signaling. This monoclonal antibody, conjugated with PERCP-Cyanine5.5 for easy detection and analysis, is specifically designed for flow cytometry applications in mouse samples.CD80, also known as B7-1, plays a crucial role in T cell activation and immune response regulation. By binding to its receptor on T cells, CD80 provides the necessary co-stimulatory signal for effective T cell activation and proliferation. Dysregulation of CD80 signaling has been implicated in various immune-related diseases, making it a target of interest in immunology and cancer research.

Researchers can use the Mouse CD80 Monoclonal Antibody to analyze the expression levels of CD80 on immune cells, investigate its role in immune activation processes, and study its potential as a therapeutic target in immunotherapy strategies. With its high specificity and validated performance in flow cytometry, this antibody is a valuable asset for understanding the intricate mechanisms of immune response modulation and developing novel therapeutic interventions.

Product Title:PerCP/Cyanine5.5 Anti-Mouse CD80 Antibody [16-10A1]
SKU:AGEL0538
Size:25µg, 100µg
Clone No:16-10A1
Synonyms:T-lymphocyte activation antigen CD80;Cd80;Activation B7-1 antigen;B7;
Host Species:Armenian Hamster
Reactivity:Mouse
Application:FCM
Isotype:Armenian Hamster IgG
Isotype Control:PerCP/Cyanine5.5 Armenian Hamster IgG Isotype Control[PIP]
Form:Liquid
Conjugation:PerCP/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q00609
Gene ID:12519
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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