Biotin Anti-Mouse CD80 Antibody [16-10A1] (AGEL0035)

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SKU:
AGEL0035
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Hamster
Isotype:
IgG
Clone:
16-10A1
Conjugation:
Biotin
Applications:
FC
Frequently bought together:

Description

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Biotin Anti-Mouse CD80 Antibody [16-10A1]

The Biotin-Conjugated Mouse CD80 Monoclonal Antibody (16-10A1) is meticulously designed for research involving CD80, a vital cell surface molecule known for its role in immune activation and costimulation. This monoclonal antibody, produced in mice, is highly specific to mouse CD80 and is validated for use in flow cytometry and immunohistochemistry applications. The biotin conjugation enhances detection and quantification through various biotin-avidin/streptavidin-based assay systems, providing precise and reliable results.CD80, also known as B7-1, is essential for the activation of T cells and modulation of immune responses through its interactions with CD28 and CTLA-4 receptors. Its pivotal role in immune response modulation makes it a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.

The Biotin-Conjugated Mouse CD80 Monoclonal Antibody (16-10A1) is an indispensable tool for researchers aiming to explore the mechanisms of immune activation and develop therapies that either enhance or suppress immune function.By facilitating accurate and sensitive detection of CD80, this antibody supports comprehensive studies of immune pathways, contributing to the advancement of immunotherapy and the development of innovative treatments for immune-related diseases. Understanding the activity of CD80 is crucial for creating targeted therapies that harness or modulate immune function, making this antibody a critical asset in advancing research in immunology and cancer.

Product Title:Biotin Anti-Mouse CD80 Antibody [16-10A1]
SKU:AGEL0035
Size:25µg, 100µg
Clone No:16-10A1
Synonyms:T-lymphocyte activation antigen CD80;Cd80;Activation B7-1 antigen;B7;
Host Species:Armenian Hamster
Reactivity:Mouse
Application:FCM
Isotype:Armenian Hamster IgG
Isotype Control:Biotin Armenian Hamster IgG Isotype Control[PIP]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q00609
Gene ID:12519
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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