The Mouse CD73 Monoclonal Antibody (TY-23) is a specialized tool for research focused on CD73, a cell surface enzyme involved in purinergic signaling and immune regulation. This monoclonal antibody, derived from mouse cells, exhibits high specificity and sensitivity for detecting CD73 in various experimental settings and is particularly well-suited for use in flow cytometry and immunohistochemistry applications.CD73, also known as ecto-5'-nucleotidase, plays a key role in purinergic signaling by catalyzing the conversion of AMP to adenosine. Adenosine generated by CD73 has multifaceted functions in the regulation of immune responses, inflammation, and tissue homeostasis. The targeted detection and analysis of CD73 using the TY-23 monoclonal antibody enable researchers to explore the molecular mechanisms underlying these processes and their implications in various physiological and pathological conditions.
The significance of CD73 in modulating the immune microenvironment and influencing immune cell behavior underscores its relevance in diverse fields such as immunology, oncology, and inflammatory diseases. By elucidating the functions of CD73 and its interactions within the purinergic pathway, scientists can uncover potential therapeutic targets for cancer immunotherapy, autoimmune disorders, and inflammatory conditions. The Mouse CD73 Monoclonal Antibody (TY-23) serves as a valuable tool for advancing research in these areas and expanding our understanding of CD73-mediated immune responses.
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD73 (ecto-5`-nucleotidase) is a 69 kD GPI-anchored surface protein. In mice, expression of CD73 in bone marrow is restricted to CD11b+ myeloid cells. In spleen, it is largely expressed on T cells.
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