The Mouse CD73 Monoclonal Antibody (PE-conjugated, TY-23) is a valuable tool for researchers studying CD73, a surface enzyme involved in immune regulation and inflammation. This monoclonal antibody, produced using hybridoma technology, specifically targets the CD73 protein and is optimized for flow cytometry applications. With high reactivity towards mouse samples, this antibody enables precise detection and analysis of CD73 expression in various cell types, making it particularly useful for studies in immunology, inflammation, and cancer research.
CD73, also known as ecto-5'-nucleotidase, plays a crucial role in adenosine production and signaling, influencing immune responses and inflammatory processes. Its involvement in regulating immune cell function and inflammation makes it a promising target for therapeutic strategies in conditions such as cancer, autoimmune diseases, and inflammatory disorders. By understanding the role of CD73 in immune modulation, researchers can uncover new therapeutic avenues for manipulating immune responses and potentially treating a range of diseases.
Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:
Swissprot:
Q61503
Gene ID:
23959
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD73 (ecto-5`-nucleotidase) is a 69 kD GPI-anchored surface protein. In mice, expression of CD73 in bone marrow is restricted to CD11b+ myeloid cells. In spleen, it is largely expressed on T cells.