PE/Cyanine7 Anti-Mouse CD62L Antibody [Mel14] (AGEL0639)

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SKU:
AGEL0639
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine7 Anti-Mouse CD62L Antibody [Mel14]

The Mouse CD62L Monoclonal Antibody (PE/Cyanine7 Conjugated, Mel14) is a powerful tool for researchers studying immune cell interactions and trafficking. This antibody, specifically designed for use in flow cytometry applications, targets CD62L, a key adhesion molecule expressed on the surface of lymphocytes, facilitating their migration into peripheral lymphoid tissues. With its PE/Cyanine7 conjugation, this antibody offers high sensitivity and specificity, enabling precise detection and analysis of CD62L-expressing cells in various experimental setups. Its monoclonal origin ensures batch-to-batch consistency and reliable performance, making it an essential resource for immunologists and researchers studying the intricate dynamics of immune cell movement and activation.

The expression of CD62L is crucial for lymphocyte homing and the formation of immune responses against pathogens or tumors. By using the Mouse CD62L Monoclonal Antibody (PE/Cyanine7 Conjugated, Mel14), researchers can gain valuable insights into the mechanisms governing immune cell trafficking and uncover novel targets for therapeutic interventions in conditions such as autoimmune diseases, inflammation, and cancer.

Product Title:PE/Cyanine7 Anti-Mouse CD62L Antibody [Mel14]
SKU:AGEL0639
Size:25µg, 100µg
Clone No:Mel14
Synonyms:L-selectin;Sell;CD62 antigen-like family member L;LAM-1;LECAM1;Lymph node homing receptor;Ly-22; CD62L;Lnhr;Ly22;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine7 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P18337
Gene ID:20343
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.

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