PE/Cyanine7 Anti-Mouse CD62L Antibody [Mel14] (AGEL0630)

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SKU:
AGEL0630
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine7 Anti-Mouse CD62L Antibody [Mel14]

The Mouse CD62L Monoclonal Antibody PE-Cyanine7 Conjugated (MEL-14) is a valuable tool for research in immunology and cell biology. This antibody specifically targets CD62L, a cell surface molecule involved in lymphocyte homing and migration. Developed for use in flow cytometry and immunofluorescence applications, the MEL-14 antibody is conjugated to PE-Cyanine7, allowing for easy visualization and quantification of CD62L-expressing cells. Its high specificity and sensitivity make it ideal for identifying and characterizing lymphocyte subpopulations in various tissues and experimental models.

CD62L, also known as L-selectin, plays a crucial role in lymphocyte trafficking and immune response regulation. By targeting CD62L with the MEL-14 antibody, researchers can gain insights into the dynamics of lymphocyte migration and activation in inflammatory responses, infection, and immune disorders. This antibody is an essential tool for studies aiming to unravel the complexities of the immune system and develop innovative therapeutic strategies for immune-related diseases.

Product Title:PE/Cyanine7 Anti-Mouse CD62L Antibody [Mel14]
SKU:AGEL0630
Size:50 Tests, 100 Tests, 200 Tests
Clone No:Mel14
Synonyms:L-selectin;Sell;CD62 antigen-like family member L;LAM-1;LECAM1;Lymph node homing receptor;Ly-22; CD62L;Lnhr;Ly22;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine7 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P18337
Gene ID:20343
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.

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