PE/Cyanine5 Anti-Mouse CD62L Antibody [Mel14] (AGEL0629)

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SKU:
AGEL0629
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
Mel14
Conjugation:
PE/Cy5
Frequently bought together:

Description

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PE/Cyanine5 Anti-Mouse CD62L Antibody [Mel14]

The Mouse CD62L Monoclonal Antibody PE-Cyanine5 Conjugated (MEL-14) is a powerful tool for researchers studying immune cell interactions and migration. This antibody, conjugated with PE-Cyanine5, specifically targets CD62L, also known as L-selectin, a key cell adhesion molecule involved in lymphocyte trafficking and homing.With high specificity and sensitivity, the MEL-14 antibody recognizes CD62L in mouse samples, enabling precise detection and analysis in flow cytometry and immunofluorescence experiments. By targeting CD62L, researchers can investigate the role of this molecule in immune cell activation, inflammation, and immune surveillance.

CD62L is critical for lymphocyte homing to secondary lymphoid organs and inflammation sites, making it a crucial molecule in immune responses. Understanding the function and regulation of CD62L is essential for unraveling complex immune processes, such as immune cell recruitment and activation in various disease contexts.The Mouse CD62L Monoclonal Antibody PE-Cyanine5 Conjugated (MEL-14) from AssayGenie provides researchers with a reliable tool to delve deeper into the mechanisms governing immune cell trafficking and responses, paving the way for advancements in immunology research and the development of novel therapeutic strategies.

Product Title:PE/Cyanine5 Anti-Mouse CD62L Antibody [Mel14]
SKU:AGEL0629
Size:50 Tests, 100 Tests, 200 Tests
Clone No:Mel14
Synonyms:L-selectin;Sell;CD62 antigen-like family member L;LAM-1;LECAM1;Lymph node homing receptor;Ly-22; CD62L;Lnhr;Ly22;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine5 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P18337
Gene ID:20343
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.

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