PE/Cyanine5.5 Anti-Mouse CD62L Antibody [Mel14] (AGEL0640)

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SKU:
AGEL0640
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine5.5 Anti-Mouse CD62L Antibody [Mel14]

The Mouse CD62L Monoclonal Antibody PE/Cyanine5.5 Conjugated (MEL-14) from Assay Genie (AGEL0640) is specifically designed for researchers studying the CD62L protein in mouse samples. CD62L, also known as L-selectin, is a cell adhesion molecule involved in lymphocyte trafficking and homing to secondary lymphoid organs. This monoclonal antibody, conjugated with both PE and Cyanine5.5 fluorophores, allows for easy visualization and analysis of CD62L expression in flow cytometry applications.The MEL-14 antibody is highly specific and reacts with mouse CD62L, enabling precise detection and quantification of this important molecule on various cell types, particularly lymphocytes.

By targeting CD62L, researchers can gain insights into immune cell migration and activation processes, making it a valuable tool for immunology studies and investigations into inflammatory responses, immune disorders, and even potential therapeutic interventions targeting lymphocyte homing mechanisms.Whether investigating immune cell trafficking in health or disease, the Mouse CD62L Monoclonal Antibody PE/Cyanine5.5 Conjugated (MEL-14) offers researchers a reliable and versatile tool for exploring the role of CD62L in immune responses and lymphocyte function in mouse models.

Product Title:PE/Cyanine5.5 Anti-Mouse CD62L Antibody [Mel14]
SKU:AGEL0640
Size:25µg, 100µg
Clone No:Mel14
Synonyms:L-selectin;Sell;CD62 antigen-like family member L;LAM-1;LECAM1;Lymph node homing receptor;Ly-22; CD62L;Lnhr;Ly22;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine5.5 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P18337
Gene ID:20343
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.

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