Purified Anti-Mouse CD62L Antibody [Mel14] (AGEL0087)

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SKU:
AGEL0087
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
Mel14
Conjugation:
Unconjugated
Applications:
FC
IHC
IP
Frequently bought together:

Description

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Purified Anti-Mouse CD62L Antibody [Mel14]

The Mouse CD62L Monoclonal Antibody (MEL-14, AGEL0087) is a vital tool for researchers studying immune cell migration and homing processes. This monoclonal antibody specifically targets CD62L, a cell surface glycoprotein also known as L-selectin, that plays a key role in mediating the adhesion and rolling of lymphocytes on endothelial cells during the immune response.Developed for use in mice, this antibody is highly specific and has been extensively validated for various applications, including flow cytometry, immunofluorescence, and immunohistochemistry. Its ability to bind to CD62L enables precise detection and visualization of lymphocytes expressing this critical homing receptor.

Researchers in immunology, inflammation, and infectious diseases will find this antibody particularly valuable for understanding the behavior of immune cells in various biological systems. By targeting CD62L, this antibody opens up new possibilities for investigating the mechanisms underlying immune cell trafficking and the development of targeted therapies for immunological disorders.For detailed studies on immune cell migration, adhesion, and inflammation, the Mouse CD62L Monoclonal Antibody (MEL-14, AGEL0087) from Assay Genie is an essential reagent that promises reliable and reproducible results for your research needs.

Product Title:Purified Anti-Mouse CD62L Antibody [Mel14]
SKU:AGEL0087
Size:25µg, 100µg
Clone No:Mel14
Synonyms:L-selectin;Sell;CD62 antigen-like family member L;LAM-1;LECAM1;Lymph node homing receptor;Ly-22; CD62L;Lnhr;Ly22;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Purified Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P18337
Gene ID:20343
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.

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