PE/Cyanine7 Anti-Mouse CD54 Antibody [YN1/1.7.4] (AGEL0715)

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SKU:
AGEL0715
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine7 Anti-Mouse CD54 Antibody [YN1/1.7.4]

The Mouse CD54 Monoclonal Antibody (PE/Cyanine7 Conjugated, YN1/1.7.4) is a specialized tool for researchers studying CD54, a key cell adhesion molecule involved in immune responses and inflammation. This monoclonal antibody, conjugated with PE/Cyanine7, provides a fluorescent marker for flow cytometry analysis, enabling precise detection of CD54 expression on cells.CD54, also known as intercellular adhesion molecule-1 (ICAM-1), plays a pivotal role in immune cell interactions by facilitating adhesion and signaling processes. Its involvement in inflammatory pathways and immune cell recruitment makes it a crucial target for investigating various immunological processes, such as leukocyte adhesion and migration.

This antibody offers high specificity and sensitivity in identifying CD54 expression, making it a valuable tool for immunologists, cell biologists, and researchers studying inflammatory diseases, immune responses, and cell adhesion mechanisms. With its validated performance in flow cytometry applications, this antibody provides reliable data for understanding the role of CD54 in immune regulation and inflammatory disorders.Overall, the Mouse CD54 Monoclonal Antibody (PE/Cyanine7 Conjugated, YN1/1.7.4) serves as a powerful instrument for elucidating the functions of CD54 in immune system dynamics, paving the way for advancements in therapeutic strategies targeting immune-related conditions.

Product Title:PE/Cyanine7 Anti-Mouse CD54 Antibody [YN1/1.7.4]
SKU:AGEL0715
Size:25µg, 100µg
Clone No:YN1/1.7.4
Synonyms:Intercellular adhesion molecule 1;Icam1;MALA-2;MyD10;CD54;Icam-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:PE/Cyanine7 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P13597
Gene ID:15894
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

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