Biotin Anti-Mouse CD54 Antibody [YN1/1.7.4] (AGEL0117)

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SKU:
AGEL0117
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2b
Clone:
YN1/1.7.4
Conjugation:
Biotin
Applications:
FC
Frequently bought together:

Description

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Biotin Anti-Mouse CD54 Antibody [YN1/1.7.4]

The Mouse CD54 Monoclonal Antibody (Biotin Conjugated, clone YN1/1.7.4) is a specialized research tool designed for the detection and analysis of CD54, a cell adhesion molecule involved in immune response and inflammation. This antibody, conjugated with biotin for versatile detection methods, is specifically engineered for use in a variety of experimental settings such as flow cytometry, immunohistochemistry, and ELISA.CD54, also known as intercellular adhesion molecule-1 (ICAM-1), plays a crucial role in immune cell interactions and the inflammatory process.

By targeting CD54, researchers can investigate mechanisms of immune cell adhesion and migration, as well as potential therapeutic interventions for conditions involving dysregulated immune responses.Utilizing the Mouse CD54 Monoclonal Antibody (Biotin Conjugated, clone YN1/1.7.4) in your research can provide valuable insights into the role of CD54 in immune-related processes and pave the way for developing novel strategies in immunology, inflammation, and infectious diseases studies.

Product Title:Biotin Anti-Mouse CD54 Antibody [YN1/1.7.4]
SKU:AGEL0117
Size:25µg, 100µg
Clone No:YN1/1.7.4
Synonyms:Intercellular adhesion molecule 1;Icam1;MALA-2;MyD10;CD54;Icam-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Biotin Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P13597
Gene ID:15894
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

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