GenieFluor 647 Anti-Mouse CD54 Antibody [YN1/1.7.4] (AGEL0719)

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SKU:
AGEL0719
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
YN1/1.7.4
Conjugation:
AF 647
Frequently bought together:

Description

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GenieFluor 647 Anti-Mouse CD54 Antibody [YN1/1.7.4]

The Mouse CD54 Monoclonal Antibody (AF647 Conjugated) (YN1/1.7.4) (AGel0719) is a cutting-edge tool designed for research involving CD54, a cell surface molecule crucial in immune responses and cell adhesion processes. This monoclonal antibody, labeled with AF647 for fluorescence detection, is created for precise detection and visualization of CD54 in various experimental settings.CD54, also known as intercellular adhesion molecule-1 (ICAM-1), plays a vital role in mediating interactions between immune cells and other cell types, contributing to processes such as leukocyte recruitment and immune signaling. Its involvement in inflammatory responses and immune cell activation makes it a key target for investigations in immunology, inflammation, and infection research.

This antibody, produced through advanced technology and rigorous validation methods, offers high specificity and sensitivity for detecting CD54 protein, allowing for accurate quantification and localization within cell populations. Its versatility in applications such as immunofluorescence, flow cytometry, and immunohistochemistry makes it an invaluable tool for unraveling the intricate mechanisms governed by CD54 in physiological and pathological conditions.Researchers aiming to explore the roles of CD54 in immune regulation, inflammation, and disease pathogenesis will greatly benefit from the precision and reliability of the Mouse CD54 Monoclonal Antibody (AF647 Conjugated) (YN1/1.7.4) (AGel0719) in their scientific inquiries.

Product Title:GenieFluor 647 Anti-Mouse CD54 Antibody [YN1/1.7.4]
SKU:AGEL0719
Size:25µg, 100µg
Clone No:YN1/1.7.4
Synonyms:Intercellular adhesion molecule 1;Icam1;MALA-2;MyD10;CD54;Icam-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:Genie Fluor 647 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:Genie Fluor647
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P13597
Gene ID:15894
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

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