APC Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1] (AGEL1402)

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SKU:
AGEL1402
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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APC Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1]

The Mouse CD45R/B220 Monoclonal Antibody (APC Conjugated) - RA3-6B2 (AGEL1402) is a crucial tool for immunological research involving the CD45R/B220 protein, particularly in studies related to B cell biology and lymphocyte differentiation. This monoclonal antibody, conjugated with APC for enhanced detection, is sourced from the RA3-6B2 hybridoma and has been rigorously validated for flow cytometry applications.CD45R/B220, a common marker for B cells and subsets of T cells, is essential for characterizing immune cell populations and studying immune responses. The specificity of this antibody allows for precise identification and quantification of B cell populations in various tissues and experimental models, enabling researchers to unravel the complexities of adaptive immune processes.

With its reliable performance in flow cytometry, the Mouse CD45R/B220 Monoclonal Antibody (APC Conjugated) - RA3-6B2 (AGEL1402) is an indispensable asset for investigations in immunology, infectious diseases, and autoimmune disorders. Its ability to distinguish B cell subsets and track their dynamics provides valuable insights into the mechanisms underlying immune function and dysfunction, paving the way for innovative therapeutic strategies targeting B cell-mediated pathologies.

Product Title:APC Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1]
SKU:AGEL1402
Size:50 Tests, 100 Tests, 200 Tests
Clone No:RA3.3A 1/6.1
Synonyms:B220;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgM, κ
Isotype Control:APC Rat IgM, κ Isotype Control[RTK2118]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Gene ID:19264,5788
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD45R, also known as B220, is an isoform of CD45. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity.

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