GenieFluor 488 Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1] (AGEL0425)

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SKU:
AGEL0425
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgM
Clone:
RA3.3A 1/6.1
Conjugation:
AF 488
Applications:
FC
Frequently bought together:

Description

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GenieFluor 488 Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1]

The Mouse CD45R/B220 Monoclonal Antibody (Alexa Fluor 488 Conjugated) - RA3-6B2 (AG200131) is a specialized tool for researchers studying immune cell populations in mice. Recognizing the CD45R/B220 antigen, which is commonly used as a marker for B cells and subsets of T cells in mice, this monoclonal antibody is conjugated with Alexa Fluor 488 for fluorescence-based assays.CD45R, also known as B220, is a transmembrane protein expressed on B cells and subsets of T cells. Its role in immune cell development, activation, and function makes it a valuable target for immunology research. By specifically binding to CD45R/B220, this antibody allows for precise detection and visualization of B cells and relevant T cell populations in experimental settings.

This antibody, derived from mouse hybridoma cells, offers high specificity and sensitivity in various applications, including flow cytometry, immunofluorescence microscopy, and immunohistochemistry. Its use can facilitate detailed analysis of immune cell dynamics, interactions, and responses in mouse models, contributing to insights on immune system regulation, autoimmune diseases, infectious conditions, and therapeutic approaches targeting B cell-mediated immune responses.For researchers investigating the complex landscape of immune cell populations in mouse models, the Mouse CD45R/B220 Monoclonal Antibody (Alexa Fluor 488 Conjugated) - RA3-6B2 (AG200131) provides a reliable tool for precise and informative immunophenotyping studies.

Product Title:GenieFluor 488 Anti-Mouse CD45R/B220 Antibody [RA3.3A 1/6.1]
SKU:AGEL0425
Size:50 Tests, 100 Tests, 200 Tests
Clone No:RA3.3A 1/6.1
Synonyms:B220;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgM, κ
Isotype Control:Genie Fluor 488 Rat IgM, κ Isotype Control[RTK2118]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Gene ID:19264,5788
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD45R, also known as B220, is an isoform of CD45. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity.

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