The Mouse CD45-2 Monoclonal Antibody PE-conjugated (104-2-AGEL1516) is a specialized antibody designed for research involving CD45-2, a key cell surface marker present on immune cells. This monoclonal antibody, produced using hybridoma technology, exhibits high specificity and sensitivity towards mouse samples, making it an essential tool for flow cytometry applications. It binds specifically to the CD45-2 antigen, enabling accurate detection and analysis in various cell populations, particularly in immunology and cell biology studies.CD45-2, also known as leukocyte common antigen, plays a crucial role in immune cell signaling and activation.
The expression levels and functions of CD45-2 are associated with immune cell development, differentiation, and response to various stimuli. Therefore, investigating CD45-2 dynamics is fundamental for understanding immune cell behavior in health and disease contexts, including infection, inflammation, and autoimmunity. This antibody serves as a valuable resource for researchers aiming to dissect the roles of CD45-2 in immune system regulation and pathology, providing insights that could lead to the development of novel therapeutic strategies.
Product Title:
PE Anti-Mouse CD45.2 Antibody [104.2]
SKU:
AGEL1516
Size:
50 Tests, 100 Tests, 200 Tests
Clone No:
104.2
Synonyms:
Ly-5.2; LCA;
Host Species:
Mouse
Reactivity:
Mouse
Application:
FCM
Isotype:
Mouse IgG2a, κ
Isotype Control:
PE Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:
Liquid
Conjugation:
PE
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Gene ID:
19264
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD45.2 is an alloantigen of CD45, expressed by Ly5.2 bearing mouse strains (e.g., A, AKR, BALB/c, CBA/Ca, CBA/J, C3H/He, C57BL, C57BR, C57L, C58, DBA/1, DBA/2, NZB, SWR, 129). CD45, a member of the protein tyrosine phosphatase (PTP) family, is a 180-240 kD glycoprotein expressed on all hematopoietic cells except mature erythrocytes and platelets. There are multiple isoforms in the mouse that play key roles in TCR and BCR signal transduction. These isoforms are very specific to the activation and maturation states of the cell as well as specific cell type. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4, TCR, CD22, and Thy-1.
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