Purified Anti-Mouse CD40 Antibody [FGK4.5/FGK45] (AGEL0140)

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SKU:
AGEL0140
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
FGK4.5/FGK45
Conjugation:
Unconjugated
Applications:
FC
Frequently bought together:

Description

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Purified Anti-Mouse CD40 Antibody [FGK4.5/FGK45]

The Mouse CD40 Monoclonal Antibody (FGK4.5) is a highly specific research tool designed for the detection and analysis of CD40, a cell surface protein involved in immune responses and immune system regulation. This monoclonal antibody, clone FGK4.5, has been generated against mouse CD40 and is suitable for various applications such as flow cytometry, immunoprecipitation, and immunohistochemistry.CD40 is a crucial co-stimulatory molecule that plays a vital role in the activation of immune cells, particularly B cells and dendritic cells. It is involved in the regulation of antibody production, T cell activation, and cytokine production. The FGK4.5 monoclonal antibody recognizes and binds specifically to mouse CD40, allowing for the precise detection and analysis of this important cell surface receptor in experimental settings.

Research involving CD40 is essential for understanding immune responses, inflammatory processes, and autoimmune diseases. By using the Mouse CD40 Monoclonal Antibody (FGK4.5), researchers can delve deeper into the mechanisms of immune modulation and explore potential therapeutic targets for conditions such as cancer, autoimmune disorders, and infectious diseases. With its high specificity and reliability, this antibody is a valuable tool for studies in immunology and biomedical research.

Product Title:Purified Anti-Mouse CD40 Antibody [FGK4.5/FGK45]
SKU:AGEL0140
Size:25µg, 100µg
Clone No:FGK4.5/FGK45
Synonyms:Tumor necrosis factor receptor superfamily member 5;Cd40;B-cell surface antigen CD40;Bp50;CD40L receptor;CD40;Tnfrsf5;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Purified Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P27512
Gene ID:21939
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation.

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