GenieFluor 488 Anti-Mouse CD40 Antibody [FGK4.5/FGK45] (AGEL0789)

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SKU:
AGEL0789
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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GenieFluor 488 Anti-Mouse CD40 Antibody [FGK4.5/FGK45]

The Mouse CD40 Monoclonal Antibody (AF488 Conjugated, FGK4.5/FGK45) is a vital tool for researchers studying the CD40 protein, a key molecule involved in immune responses and cell signaling. This antibody, conjugated with AF488 for fluorescence detection, is specifically designed for use in flow cytometry and immunofluorescence applications.CD40, a member of the tumor necrosis factor receptor superfamily, plays a crucial role in immune regulation and activation of immune cells such as B cells, dendritic cells, and macrophages. By targeting CD40 with this monoclonal antibody, researchers can effectively label and track the expression of CD40 on cell surfaces, facilitating the study of its functions in various biological processes.

The FGK4.5/FGK45 monoclonal antibody provides high specificity and sensitivity in detecting mouse CD40, making it a valuable tool for investigating immune responses, inflammation, and potential therapeutic targets in diseases like cancer, autoimmune disorders, and infectious diseases. By utilizing this antibody, researchers can gain valuable insights into the intricate mechanisms of immune system modulation and potential treatment strategies.

Product Title:GenieFluor 488 Anti-Mouse CD40 Antibody [FGK4.5/FGK45]
SKU:AGEL0789
Size:25µg, 100µg
Clone No:FGK4.5/FGK45
Synonyms:Tumor necrosis factor receptor superfamily member 5;Cd40;B-cell surface antigen CD40;Bp50;CD40L receptor;CD40;Tnfrsf5;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 488 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P27512
Gene ID:21939
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation.

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