APC Anti-Mouse CD366/Tim-3 Antibody [RMT3-23] (AGEL2006)

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SKU:
AGEL2006
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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APC Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]

The Mouse CD366 (TIM-3) Monoclonal Antibody (APC Conjugated, RMT3-23) is a specialized tool designed for researchers studying TIM-3, a critical immune checkpoint receptor involved in regulating immune responses. This monoclonal antibody, conjugated with APC for enhanced detection sensitivity, is specifically tailored for use in flow cytometry applications.TIM-3, also known as T-cell immunoglobulin and mucin-domain containing-3, is a key regulator of T cell function and immune tolerance. Its interaction with galectin-9 plays a crucial role in controlling immune responses, including T cell exhaustion and cytokine production. The Mouse CD366 Monoclonal Antibody binds specifically to TIM-3 protein, enabling precise detection and characterization in various immune cell populations.

Understanding the role of TIM-3 in immune regulation is essential for unraveling its implications in diseases such as cancer, chronic infections, and autoimmune disorders. By targeting TIM-3, researchers aim to develop innovative immunotherapeutic strategies that modulate immune responses for improved treatment outcomes. The Mouse CD366 (TIM-3) Monoclonal Antibody (APC Conjugated, RMT3-23) serves as a valuable resource for studies focusing on immune checkpoint blockade mechanisms and their therapeutic potential.

Product Title:APC Anti-Mouse CD366/Tim-3 Antibody [RMT3-23]
SKU:AGEL2006
Size:50 Tests, 100 Tests, 200 Tests
Clone No:RMT3-23
Synonyms:TIM3; TIMD3;HAVcr-2;TIMD-3;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q8VIM0
Gene ID:84868
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

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