PE/Cyanine5.5 Anti-Mouse CD274/PD-L1 Antibody [10F.9G2] (AGEL1641)

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SKU:
AGEL1641
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
10F.9G2
Conjugation:
PE/Cy5.5
Frequently bought together:

Description

PE/Cyanine5.5 Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]

The Mouse CD274 (PD-L1) Monoclonal Antibody PE-Cyanine5.5 Conjugated (10F.9G2) is a powerful tool for research in the fields of immunology and cancer biology. This antibody, produced by Assay Genie, specifically targets the CD274 (PD-L1) protein, also known as Programmed Death-Ligand 1. CD274 (PD-L1) is a key immune checkpoint protein that plays a critical role in immune regulation and evasion by certain cancer cells. By binding to its receptor, PD-1, on T cells, CD274 (PD-L1) inhibits the immune response and allows cancer cells to evade detection and attack. Understanding the expression and function of CD274 (PD-L1) is crucial for developing immunotherapies that target this pathway to enhance anti-tumor immune responses.

The PE-Cyanine5.5 conjugation of this antibody makes it suitable for flow cytometry applications, enabling precise detection and analysis of CD274 (PD-L1) expression on the surface of cells. This antibody is highly specific for mouse samples and has been rigorously validated for use in research studies. Researchers studying immune modulation, cancer immunology, and immune checkpoint therapies will find the Mouse CD274 (PD-L1) Monoclonal Antibody PE-Cyanine5.5 Conjugated (10F.9G2) to be a valuable asset for their investigations. Unlock the potential of immune checkpoint blockade and cancer immunotherapy with this cutting-edge antibody from Assay Genie.

Antibody Name:Mouse CD274/PD-L1 Monoclonal Antibody (PE/Cyanine5.5 Conjugated)
Antibody Code:AGEL1641
Size:50 Tests
Clone:10F.9G2
Synonyms:B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
Host Species:Rat
Species Reactivity:Mouse
Applications:FC
Concentration:5uL
Isotype:IgG2a,k
Conjugation:PE/Cyanine5.5
Applications:FC
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 5 uL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Storage Buffer:PBS with 0.05% Proclin300, 1% BSA
Storage:Store at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Gene ID:60533
Uniprot:Q9EP73
Background:CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
Mouse CD19 Monoclonal Antibody (FITC Conjugated)C57BL/6 murine splenocytes are stained with Anti-Mouse PD-L1 Monoclonal Antibody(PE/Cyanine5.5 Conjugated)(filled gray histogram). Unstained splenocytes (empty black histogram) are used as control.

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