PE Anti-Mouse CD274/PD-L1 Antibody [10F.9G2] (AGEL1639)

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SKU:
AGEL1639
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
10F.9G2
Conjugation:
PE
Frequently bought together:

Description

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PE Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]

The mouse CD274 (PD-L1) Monoclonal Antibody (PE Conjugated, 10F.9G2) is a valuable tool for researchers studying immune responses and immunotherapy. This antibody, specifically designed for use in flow cytometry applications, targets the CD274 protein, also known as PD-L1, a critical immune checkpoint molecule involved in regulating T cell activation and tolerance.PD-L1, a key player in the immune system, interacts with its receptor PD-1 to inhibit T cell activation, thereby preventing excessive immune responses and maintaining immune tolerance. Dysregulation of the PD-L1/PD-1 pathway is associated with immune evasion in cancer and chronic infections, making it a promising target for immunotherapy interventions.

The PE-conjugated 10F.9G2 antibody provides a reliable tool for detecting and quantifying PD-L1 expression on the surface of mouse cells, allowing researchers to explore the role of PD-L1 in immune evasion mechanisms and develop novel strategies for enhancing anti-tumor immunity. With its high specificity and sensitivity, this antibody is an essential component in studies focusing on immune checkpoint blockade and cancer immunotherapy.

Product Title:PE Anti-Mouse CD274/PD-L1 Antibody [10F.9G2]
SKU:AGEL1639
Size:50 Tests, 100 Tests, 200 Tests
Clone No:10F.9G2
Synonyms:B7-H1; PD-L1;Programmed cell death ligand 1;B7 homolog 1;B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:PE Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q9EP73
Gene ID:60533
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

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