Biotin Anti-Mouse CD272 Antibody [PK18.6] (AGEL0134)

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SKU:
AGEL0134
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG1k
Clone:
PK18.6
Conjugation:
Biotin
Applications:
FC
Frequently bought together:

Description

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Biotin Anti-Mouse CD272 Antibody [PK18.6]

The Mouse CD272 Monoclonal Antibody (Biotin Conjugated) is a specialized research tool designed for the detection and analysis of CD272, a crucial cell surface molecule involved in immune regulation. This antibody, generated through monoclonal techniques, exhibits high reactivity specifically with mouse samples, offering reliable results in various experimental applications.CD272, also known as B and T lymphocyte attenuator (BTLA), functions as an inhibitory receptor in the immune system, playing a pivotal role in modulating immune responses. It is particularly significant in maintaining immune tolerance and controlling immune activation, making it a key player in immunological processes. Research focusing on CD272 holds promise in deepening our understanding of immune regulation mechanisms, with implications for fields such as immunotherapy and autoimmune disease research.

The biotin conjugation of this CD272 monoclonal antibody enhances its utility in applications like immunohistochemistry, flow cytometry, and other immunodetection methods. Its specificity for CD272 protein enables precise detection and characterization of this molecule in diverse cell types, presenting valuable opportunities for investigating immune response pathways and therapeutic targets.For scientists studying immunology, cancer biology, or autoimmune disorders, the Mouse CD272 Monoclonal Antibody (Biotin Conjugated) serves as a reliable tool for delving into the intricate mechanisms of immune regulation mediated by CD272. By facilitating accurate detection and analysis of this critical molecule, this antibody supports impactful research aimed at advancing our knowledge of immune system function and its implications for human health.

Product Title:Biotin Anti-Mouse CD272 Antibody [PK18.6]
SKU:AGEL0134
Size:25µg, 100µg
Clone No:PK18.6
Synonyms:B- and T-lymphocyte attenuator;Btla;B- and T-lymphocyte-associated protein;CD272;Btla;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:Biotin Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q7TSA3
Gene ID:208154
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

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