APC Anti-Mouse CD272 Antibody [PK18.6] (AGEL0756)

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SKU:
AGEL0756
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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APC Anti-Mouse CD272 Antibody [PK18.6]

The Mouse CD272 Monoclonal Antibody (APC-conjugated) (PK18-6) is a cutting-edge research tool designed for scientists studying immune responses and immune regulation. This antibody, developed by Assay Genie, specifically targets the CD272 protein, aiding in the detection and analysis of this key immune molecule in various cell types. CD272, also known as B- and T-lymphocyte attenuator (BTLA), is a critical immune checkpoint receptor that can modulate immune responses. Its role in regulating immune activation and tolerance makes it a promising target for therapeutic interventions in conditions such as cancer, autoimmune diseases, and inflammatory disorders.

By using the Mouse CD272 Monoclonal Antibody (APC-conjugated), researchers can gain insights into the function of CD272 and potentially identify new pathways for immunotherapy development. This antibody is highly specific and reliable, making it an essential tool for immunology and cancer research. With its APC-conjugated formulation, it provides a fluorescent signal for easy detection and imaging, enhancing the efficiency and accuracy of experiments. Trust in the Mouse CD272 Monoclonal Antibody (APC-conjugated) (PK18-6) from Assay Genie to advance your research in immune regulation and immune-related diseases.

Product Title:APC Anti-Mouse CD272 Antibody [PK18.6]
SKU:AGEL0756
Size:50 Tests, 100 Tests, 200 Tests
Clone No:PK18.6
Synonyms:B- and T-lymphocyte attenuator;Btla;B- and T-lymphocyte-associated protein;CD272;Btla;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:APC Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q7TSA3
Gene ID:208154
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

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