Mouse CD25 monoclonal antibody (APC) (AGIM0553)
- SKU:
- AGIM0553
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rat
- Isotype:
- IgG1
- Clone:
- PC61.5.3
- Conjugation:
- APC
- Applications:
- FC
Description
| Product Name: | Mouse CD25 monoclonal antibody (APC) |
| Product Code: | AGIM0553 |
| Size: | 100 µL |
| Reactivity: | Mouse |
| Clone: | PC61.5.3 |
| Applications: | Flow Cytometry |
| Conjugate: | APC |
| Isotype: | IgG1 |
| Host Species: | Rat |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P01590 |
| Background: | CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitutes the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55 kDa CD25 molecule is enzymatically cleaved and shed from the cell surface as a soluble 45 kDa s-Tac, whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. CD25+ CD4+ FoxP3+ regulatory cells (Treg cells) play a crucial role in the control of organ-specific autoimmune diseases. |
| UniProt Protein Function: | IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Cellular Component: cell surface; membrane; integral to membrane; external side of plasma membrane Molecular Function:protein binding; interleukin-2 receptor activity; drug binding; interleukin-2 binding Biological Process: Notch signaling pathway; regulation of T cell homeostatic proliferation; negative regulation of immune response; negative regulation of defense response to virus; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; inflammatory response to antigenic stimulus; negative regulation of T cell proliferation; positive regulation of T cell differentiation; negative regulation of inflammatory response; T cell homeostasis; positive regulation of T cell proliferation; immune response; activated T cell apoptosis |
| UniProt Code: | P01590 |
| NCBI GenInfo Identifier: | 124318 |
| NCBI Gene ID: | 16184 |
| NCBI Accession: | P01590.1 |
| UniProt Related Accession: | P01590 |
| Molecular Weight: | |
| NCBI Full Name: | Interleukin-2 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 2 receptor, alpha chain |
| NCBI Official Symbol: | Il2ra |
| NCBI Official Synonym Symbols: | CD25; Il2r; Ly-43 |
| NCBI Protein Information: | interleukin-2 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-2 receptor subunit alpha |
| UniProt Synonym Protein Names: | p55; CD_antigen: CD25 |
| UniProt Gene Name: | Il2ra |
| UniProt Entry Name: | IL2RA_MOUSE |
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