PerCP/Cyanine5.5 Anti-Mouse CD22 Antibody [Cy34.1] (AGEL0735)

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SKU:
AGEL0735
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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PerCP/Cyanine5.5 Anti-Mouse CD22 Antibody [Cy34.1]

The Mouse CD22 Monoclonal Antibody (PerCP-Cyanine5.5 Conjugated, Clone CY34.1) is a powerful tool for researchers investigating CD22, a cell surface glycoprotein associated with B-cell activation and function. This antibody, derived from a unique monoclonal hybridoma, exhibits high specificity and sensitivity for mouse CD22, making it perfect for flow cytometry applications in immunology and related fields.CD22, a member of the sialic acid-binding Ig-like lectin (Siglec) family, is primarily expressed on B-lymphocytes and plays a crucial role in regulating B-cell signaling and activation. Its intricate involvement in B-cell function, including modulation of antigen receptor signaling and tolerance induction, makes it a key target for understanding immune responses and potential therapeutic interventions.

By utilizing the Mouse CD22 Monoclonal Antibody (PerCP-Cyanine5.5 Conjugated, Clone CY34.1), researchers can accurately detect and analyze CD22 expression on B-cells in various experimental settings. This antibody's exceptional performance and reliability ensure precise and consistent results, facilitating detailed investigations into B-cell biology, immunological processes, and disease mechanisms where CD22 signaling is implicated.Enhance your research capabilities and gain valuable insights into B-cell biology and immune system regulation with the Mouse CD22 Monoclonal Antibody (PerCP-Cyanine5.5 Conjugated, Clone CY34.1). Unlock the potential of CD22-related studies and advance your understanding of immunological processes with this high-quality antibody reagent.

Product Title:PerCP/Cyanine5.5 Anti-Mouse CD22 Antibody [Cy34.1]
SKU:AGEL0735
Size:25µg, 100µg
Clone No:Cy34.1
Synonyms:B-cell receptor CD22;Cd22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;Lyb-8; Siglec2;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PerCP/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PerCP/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P35329
Gene ID:12483
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.

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