PerCP/Cyanine5.5 Anti-Mouse CD22 Antibody [Cy34.1] (AGEL0726)

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SKU:
AGEL0726
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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PerCP/Cyanine5.5 Anti-Mouse CD22 Antibody [Cy34.1]

The Mouse CD22 Monoclonal Antibody (PerCP-Cyanine5.5 Conjugated, clone: Cy34.1) from Assay Genie (AGel0726) is a highly specific antibody designed for research applications involving CD22, a cell surface protein primarily found on B cells. This monoclonal antibody, derived from mice, offers excellent reactivity with mouse samples and is validated for flow cytometry and immunofluorescence applications.CD22, a member of the immunoglobulin superfamily, acts as a regulator of B cell activation and proliferation. It plays a crucial role in modulating B cell signaling and function, making it a key target for investigations in immunology and autoimmune diseases. With the ability to specifically bind to CD22, researchers can effectively analyze and characterize B cell populations in various experimental settings, providing valuable insights into B cell biology and immune responses.

By utilizing the Mouse CD22 Monoclonal Antibody (PerCP-Cyanine5.5 Conjugated, clone: Cy34.1), researchers can advance their studies in immunology, hematology, and related fields, enhancing their understanding of B cell function and the role of CD22 in immune regulation. This antibody holds promise for unraveling complex mechanisms underlying B cell-mediated immunity and exploring potential therapeutic strategies for immune-related disorders.

Product Title:PerCP/Cyanine5.5 Anti-Mouse CD22 Antibody [Cy34.1]
SKU:AGEL0726
Size:50 Tests, 100 Tests, 200 Tests
Clone No:Cy34.1
Synonyms:B-cell receptor CD22;Cd22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;Lyb-8; Siglec2;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PerCP/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PerCP/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P35329
Gene ID:12483
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.

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