PE/Cyanine7 Anti-Mouse CD22 Antibody [Cy34.1] (AGEL0733)

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SKU:
AGEL0733
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine7 Anti-Mouse CD22 Antibody [Cy34.1]

The Mouse CD22 Monoclonal Antibody (PE-Cyanine7 Conjugated) (CY34-1) is a vital tool for researchers studying CD22, a B-cell specific transmembrane glycoprotein that plays a crucial role in B-cell activation and development. This monoclonal antibody, conjugated with PE-Cyanine7 for enhanced detection capabilities, is specifically designed for flow cytometry applications, allowing for precise analysis of CD22 expression on mouse cells.CD22 is known for its regulatory functions in B-cell signaling and immune responses, making it a key target in immunology and hematological research. By utilizing this monoclonal antibody, researchers can accurately identify and quantify CD22-expressing cells in various experimental settings, providing valuable insights into B-cell biology, autoimmune diseases, and potential therapeutic strategies targeting CD22.

The validation of this antibody for flow cytometry ensures reliable and reproducible results, making it an essential reagent for scientists investigating the role of CD22 in immune responses, B-cell malignancies, and autoimmune disorders. Enhance your research with the Mouse CD22 Monoclonal Antibody (PE-Cyanine7 Conjugated) (CY34-1) and unlock new possibilities in the study of B-cell biology and related diseases.

Product Title:PE/Cyanine7 Anti-Mouse CD22 Antibody [Cy34.1]
SKU:AGEL0733
Size:25µg, 100µg
Clone No:Cy34.1
Synonyms:B-cell receptor CD22;Cd22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;Lyb-8; Siglec2;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine7 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P35329
Gene ID:12483
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.

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