PE/Cyanine5.5 Anti-Mouse CD22 Antibody [Cy34.1] (AGEL0734)

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SKU:
AGEL0734
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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PE/Cyanine5.5 Anti-Mouse CD22 Antibody [Cy34.1]

The Mouse CD22 Monoclonal Antibody PE/Cyanine5.5 Conjugated (Clone: CY34.1) is a powerful tool designed for researchers studying CD22, a B cell-specific receptor that plays a crucial role in B cell activation and regulation. This antibody, produced through monoclonal techniques, is specifically conjugated with PE/Cyanine5.5 for fluorescence-based detection methods.CD22, a member of the immunoglobulin superfamily, is primarily expressed on B cells and is involved in regulating B cell signaling and activation. Its significance in B cell biology and immune response modulation makes it a valuable target for research in immunology and related fields.

The Mouse CD22 Monoclonal Antibody PE/Cyanine5.5 Conjugated (Clone: CY34.1) binds specifically to CD22, making it an excellent tool for flow cytometry, immunofluorescence, and other cellular analysis techniques. This antibody enables accurate detection and analysis of CD22 expression in various cell populations, facilitating further insights into B cell function and potential therapeutic interventions in diseases related to B cell dysregulation.

Product Title:PE/Cyanine5.5 Anti-Mouse CD22 Antibody [Cy34.1]
SKU:AGEL0734
Size:25µg, 100µg
Clone No:Cy34.1
Synonyms:B-cell receptor CD22;Cd22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;Lyb-8; Siglec2;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P35329
Gene ID:12483
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.

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