APC Anti-Mouse CD22 Antibody [Cy34.1] (AGEL0731)

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SKU:
AGEL0731
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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APC Anti-Mouse CD22 Antibody [Cy34.1]

The Mouse CD22 Monoclonal Antibody (APC Conjugated, CY34.1) is a valuable tool for research in immunology and related fields. CD22 is a cell surface glycoprotein that plays a crucial role in B cell function, specifically in the regulation of B cell activation and signaling. This monoclonal antibody, conjugated with APC for enhanced detection, is specifically designed to bind to the CD22 protein, enabling its detection and analysis in various experimental settings.The CY34.1 antibody is highly specific to mouse CD22, making it an ideal choice for studies involving mouse models of immune responses, autoimmune diseases, and B cell-related disorders.

Its ability to target CD22 allows researchers to explore the functions of this important protein in regulating B cell development, activation, and tolerance.With its high reactivity and specificity, the Mouse CD22 Monoclonal Antibody (APC Conjugated, CY34.1) is a valuable resource for investigators conducting research in immunology, cancer biology, and autoimmune disease. By facilitating the identification and characterization of CD22-expressing cells, this antibody supports the advancement of knowledge in B cell biology and the development of potential therapeutics targeting CD22-mediated pathways.

Product Title:APC Anti-Mouse CD22 Antibody [Cy34.1]
SKU:AGEL0731
Size:25µg, 100µg
Clone No:Cy34.1
Synonyms:B-cell receptor CD22;Cd22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;Lyb-8; Siglec2;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:APC Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P35329
Gene ID:12483
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb.

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