FITC Anti-Mouse CD206 Antibody [C068C2] (AGEL1654)

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SKU:
AGEL1654
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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FITC Anti-Mouse CD206 Antibody [C068C2]

The Mouse CD206 Monoclonal Antibody FITC Conjugated (C068C2-AGEL1654) is a vital tool for researchers studying CD206, a key marker for macrophages involved in immune responses and tissue repair. This monoclonal antibody, raised in mice, is specifically conjugated with FITC for fluorescence detection, making it suitable for flow cytometry and immunofluorescence applications.CD206, also known as mannose receptor, plays a pivotal role in recognizing and internalizing glycoproteins, contributing to antigen presentation and immune regulation. Its expression is particularly prevalent in macrophages and dendritic cells, where it is involved in phagocytosis and antigen processing.

The ability of this antibody to target CD206 allows for precise visualization and quantification of CD206-expressing cells in various tissues and experimental settings.Researchers studying immunology, inflammation, and infectious diseases will benefit from the use of this mouse CD206 monoclonal antibody. By elucidating the functions of CD206 in immune responses, researchers can better understand the role of macrophages in health and disease, potentially leading to the development of more targeted therapies for conditions such as infection, inflammation, and cancer.

Product Title:FITC Anti-Mouse CD206 Antibody [C068C2]
SKU:AGEL1654
Size:25µg, 100µg
Clone No:C068C2
Synonyms:MMR;MR;MRC1;macrophage mannose receptor;mannose receptor ;
Host Species:Rat
Reactivity:Mouse
Application:FCM;ICFCM
Isotype:Rat IgG2a, κ
Isotype Control:FITC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q61830
Gene ID:17533
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

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