The Mouse CD1d Monoclonal Antibody (PE/Cyanine7 Conjugated, 19G11, AGEL0812) is a vital tool for researchers studying the CD1d protein in mice. This monoclonal antibody, conjugated with PE/Cyanine7, specifically targets the CD1d molecule, a key player in antigen presentation to natural killer T (NKT) cells. By binding to CD1d, this antibody allows for the visualization and analysis of CD1d expression in various cell types, facilitating investigations in immunology and host defense mechanisms.CD1d is a major histocompatibility complex (MHC) class I-like molecule that presents lipid antigens to NKT cells, regulating immune responses and contributing to the body's defense against infections and tumors.
Understanding the role of CD1d in antigen presentation and immune activation is essential for advancing knowledge in areas such as immunotherapy, infectious diseases, and autoimmune disorders. The Mouse CD1d Monoclonal Antibody (PE/Cyanine7 Conjugated, 19G11, AGEL0812) provides a reliable tool for researchers to delve deeper into the complex interactions involving CD1d, NKT cells, and immune responses in mouse models.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P11609
Gene ID:
12479
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD1d is a type I transmembrane protein and member of the MHC family, with a molecular weight ranging from 43-49 kD, depending on the glycosylation degree. CD1d is expressed by antigen presenting cells such as dendritic cells, monocytes, macrophages and B cells; also expressed by thymocytes and intestinal epithelial cells. CD1d present glycolipids to iNKT cells that recognize them by their Vα14i TCR.