The Mouse CD1d Monoclonal Antibody (PE-Cyanine5.5 Conjugated, 19G11, AGEL0821) offered by AssayGenie is a vital tool for researchers studying immune responses and antigen presentation in mouse models. This antibody specifically targets CD1d, a type I transmembrane glycoprotein that plays a key role in presenting lipid antigens to Natural Killer T (NKT) cells.By utilizing the 19G11 antibody conjugated with PE-Cyanine5.5, researchers can efficiently detect and analyze CD1d expression in various cell types using flow cytometry and fluorescence-based assays. This allows for detailed investigations into the function and regulation of CD1d-mediated antigen presentation, aiding in the understanding of immune responses and the development of immunotherapies.
The high specificity and sensitivity of the AGEL0821 antibody make it a reliable tool for immunology research, particularly in the fields of autoimmunity, infectious diseases, and cancer immunology. With its ability to accurately target and detect mouse CD1d, this antibody is essential for advancing our knowledge of immune system regulation and therapeutic development.
Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:
Swissprot:
P11609
Gene ID:
12479
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD1d is a type I transmembrane protein and member of the MHC family, with a molecular weight ranging from 43-49 kD, depending on the glycosylation degree. CD1d is expressed by antigen presenting cells such as dendritic cells, monocytes, macrophages and B cells; also expressed by thymocytes and intestinal epithelial cells. CD1d present glycolipids to iNKT cells that recognize them by their Vα14i TCR.