The Mouse CD19 Monoclonal Antibody, FITC Conjugated (1D3) is designed for research focused on CD19, a key cell surface molecule critical for B-cell development, activation, and differentiation. This monoclonal antibody, derived from mice, is conjugated with fluorescein isothiocyanate (FITC), providing robust fluorescence for accurate detection in flow cytometry applications.CD19 is an integral marker for B-cell lineage identification and plays a significant role in B-cell signal transduction. The FITC conjugation of this antibody enhances its utility in highly sensitive fluorescence-based detection, making it ideal for studies in immunology, oncology, and autoimmune research.
The Mouse CD19 Monoclonal Antibody, FITC Conjugated (1D3), facilitates precise identification and analysis of B-cells, aiding research into B-cell malignancies such as lymphomas and leukemias, as well as autoimmune disorders like rheumatoid arthritis and lupus.Understanding the function and activity of CD19 is crucial for developing targeted therapies that modulate B-cell function. This antibody is an invaluable tool for researchers aiming to elucidate B-cell mechanisms, thereby driving advancements in the treatment of B-cell-related diseases.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P25918
Gene ID:
12478
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD19 is a 95 kD glycoprotein also known as B4. It is a member of the Ig superfamily, expressed on all pro-B to mature B cells (during development) and follicular dendritic cells. Plasma cells do not express CD19. CD19, in association with CD21 and CD81, forms a molecular complex integral to B cell activation.