Biotin Anti-Mouse CD18 Antibody [M18/2] (AGEL0427)

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SKU:
AGEL0427
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
M12/2
Conjugation:
Biotin
Applications:
FC
Frequently bought together:

Description

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Biotin Anti-Mouse CD18 Antibody [M18/2]

The Mouse CD18 Monoclonal Antibody (Biotin Conjugated, M12/2) is a specialized research tool offered by AssayGenie for studies involving CD18, a crucial cell surface molecule involved in immune responses, particularly in cell adhesion and migration processes. This monoclonal antibody, produced for mouse samples, is conjugated with biotin for enhanced detection and is validated for various applications, including flow cytometry and immunohistochemistry.CD18, also known as integrin beta-2, plays a pivotal role in mediating interactions between leukocytes and endothelial cells during inflammation and immune surveillance. Its involvement in cell adhesion and transmigration across endothelial barriers makes it a key player in immune system function and inflammatory responses.

Researchers studying immunology, inflammation, and infectious diseases can benefit from using this antibody to detect and analyze CD18 expression in different cell types and tissues.The specific binding of the Mouse CD18 Monoclonal Antibody enables precise detection and characterization of CD18 expression patterns, aiding in the understanding of immune cell behavior and function in various physiological and pathological conditions. This antibody is a valuable tool for investigating the role of CD18 in immune cell recruitment, activation, and tissue infiltration, offering insights that can inform the development of targeted therapies for inflammatory disorders and immune-related diseases.

Product Title:Biotin Anti-Mouse CD18 Antibody [M18/2]
SKU:AGEL0427
Size:25µg, 100µg
Clone No:M18/2
Synonyms:Integrin beta-2;Itgb2;Cell surface adhesion glycoproteins LFA-1/CR3/p150+95 subunit beta;Complement receptor C3 subunit beta;CD18;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Biotin Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P11835
Gene ID:16414
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD18 is a 95 kD protein, also known as integrin β2 subunit. It is expressed on all leukocytes. CD18, in association with integrin α chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and αXβ2, respectively, and plays an important role in leukocytes adhesion. The CD18 integrin complexes bind ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, and fibrinogen.

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