PE/Cyanine7 Anti-Mouse CD161/NK1.1 Antibody [PK136] (AGEL0480)

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SKU:
AGEL0480
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Mouse
Isotype:
IgG2a,k
Clone:
PK136
Conjugation:
PE/Cy7
Frequently bought together:

Description

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PE/Cyanine7 Anti-Mouse CD161/NK1.1 Antibody [PK136]

The Mouse CD161/NK1.1 Monoclonal Antibody (PE/Cyanine7 Conjugated) (PK136) is a powerful tool for researchers studying natural killer (NK) cells and immune responses in mice. This antibody, conjugated with PE/Cyanine7, specifically targets CD161 and NK1.1, important cell surface markers associated with NK cell activity and functions.NK cells are critical components of the innate immune system, playing key roles in the early defense against pathogens and tumor cells. The CD161/NK1.1 antibody enables precise detection and analysis of NK cells in various mouse tissues and experimental models. Its high specificity and sensitivity make it an invaluable resource for immunology studies focusing on NK cell biology, host defense, and immunotherapy research.

By targeting CD161 and NK1.1, researchers can gain insights into the regulation and function of NK cells in different physiological and pathological conditions. This antibody is rigorously validated for flow cytometry applications, providing reliable and reproducible results for investigating NK cell subsets, activation status, and interactions within the immune system.Overall, the Mouse CD161/NK1.1 Monoclonal Antibody (PE/Cyanine7 Conjugated) (PK136) is a cutting-edge tool that empowers scientists to explore the intricate roles of NK cells in immunity, inflammation, and disease, driving advancements in immunological research and therapeutic development.

Product Title:PE/Cyanine7 Anti-Mouse CD161/NK1.1 Antibody [PK136]
SKU:AGEL0480
Size:50 Tests, 100 Tests, 200 Tests
Clone No:PK136
Synonyms:Killer cell lectin-like receptor subfamily B member 1C;Klrb1c;CD161 antigen-like family member C;Ly-55c;CD161/NK1.1;NKR-P1.9;NKR-P1C;NKR-P1 40;CD161c;
Host Species:Mouse
Reactivity:Mouse
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:PE/Cyanine7 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P27814 P27812 Q99JB4
Gene ID:17059
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

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