PE Anti-Mouse CD14 Antibody [Sa14-2] (AGEL1873)

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SKU:
AGEL1873
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
Sa14-2
Conjugation:
PE
Frequently bought together:

Description

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PE Anti-Mouse CD14 Antibody [Sa14-2]

The Mouse CD14 Monoclonal Antibody PE-Conjugated (SA14-2) is a vital tool for researchers studying immune responses and inflammatory processes in mouse models. This antibody specifically targets CD14, a key protein involved in the recognition of pathogen-associated molecular patterns (PAMPs) and activation of innate immune responses.CD14 is predominantly expressed on the surface of macrophages and monocytes, where it plays a crucial role in the recognition and clearance of bacterial components such as lipopolysaccharides (LPS). By binding to CD14, this monoclonal antibody enables the detection and analysis of CD14-expressing cells in various tissues and biological samples.

Utilizing this PE-conjugated antibody in flow cytometry or immunofluorescence assays allows for precise identification and quantification of CD14-positive cell populations, aiding in the study of immune system activation, infection, and inflammation in mouse models. Researchers can further investigate the roles of CD14 in diseases such as sepsis, atherosclerosis, and other inflammatory conditions, potentially leading to the development of targeted therapies and treatment strategies.

Product Title:PE Anti-Mouse CD14 Antibody [Sa14-2]
SKU:AGEL1873
Size:25µg, 100µg
Clone No:Sa14-2
Synonyms:CD 14;Myeloid cell-specific leucine-rich glycoprotein;Monocyte differentiation antigen CD14;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P10810
Gene ID:12475
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD14 is a 53-55 kD glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein also known as LPS receptor. CD14 is expressed on macrophages, dendritic cells, Kupffer cells, hepatocytes, and granulocytes. As a high-affinity receptor for LPS-LBP (LPS-binding protein) complex, CD14, in association with Toll-like Receptor 4 (TLR4) or 2 (TLR2), is involved in the clearance of gram-negative pathogens.

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