PE Anti-Mouse CD122 Antibody [5H4] (AGEL0800)

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SKU:
AGEL0800
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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PE Anti-Mouse CD122 Antibody [5H4]

The Mouse CD122 Monoclonal Antibody (PE Conjugated, 5H4, AGEL0800) is a cutting-edge tool designed for researchers studying immune cells in mice. This antibody specifically targets CD122, a crucial protein involved in immune cell signaling, particularly in the regulation of T-cell function and differentiation. The antibody is monoclonal, ensuring high specificity and sensitivity in detecting CD122 in various mouse cell types.By binding to CD122 with precision, this antibody enables accurate detection and analysis of immune cells expressing this key receptor. Its PE conjugation allows for fluorescence-based assays, such as flow cytometry, facilitating the identification and sorting of specific cell populations for further research.

CD122, also known as the interleukin-2 receptor beta chain, plays a pivotal role in mediating T-cell activation and proliferation, making it a significant target for investigating immune responses and therapeutic interventions. Research using this antibody can shed light on the mechanisms underlying immune regulation, inflammation, and autoimmune diseases in mouse models.Whether studying immune system dynamics, cytokine signaling, or immune-related disorders, the Mouse CD122 Monoclonal Antibody (PE Conjugated, 5H4, AGEL0800) is an invaluable resource for researchers seeking to deepen their understanding of immune cell function in mice and advance the field of immunology.

Product Title:PE Anti-Mouse CD122 Antibody [5H4]
SKU:AGEL0800
Size:25µg, 100µg
Clone No:5H4
Synonyms:Interleukin-2 receptor subunit beta;Il2rb;IL-2 receptor subunit beta; IL-2R subunit beta;IL-2RB;High affinity IL-2 receptor subunit beta;p70-75;CD122;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P16297
Gene ID:16185
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

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