PE Anti-Mouse CD122 Antibody [5H4] (AGEL0792)

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SKU:
AGEL0792
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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PE Anti-Mouse CD122 Antibody [5H4]

The Mouse CD122 Monoclonal Antibody (PE Conjugated) - 5H4 (AGEL0792) is a valuable tool for researchers studying immune responses and cell signaling pathways. This PE-conjugated monoclonal antibody specifically targets CD122, a receptor subunit involved in cytokine signaling, particularly in the regulation of immune cell function.CD122, also known as the interleukin-2 receptor beta chain, plays a crucial role in the activation and proliferation of T cells and natural killer cells. By specifically targeting CD122, this monoclonal antibody allows for the detection and analysis of this important receptor in various cell types, providing insights into immune response mechanisms.The PE conjugation of this antibody enhances its utility by allowing for flow cytometry applications, enabling researchers to visualize and quantify CD122 expression on cell surfaces with high sensitivity.

This feature makes the 5H4 monoclonal antibody an ideal choice for studies in immunology, infectious diseases, and cancer research.By understanding the role of CD122 in immune regulation and cell signaling, researchers can gain valuable insights into therapeutic strategies for modulating immune responses in conditions such as autoimmune diseases, infectious diseases, and cancer. The Mouse CD122 Monoclonal Antibody (PE Conjugated) - 5H4 (AGEL0792) is a reliable tool for investigating the intricate dynamics of immune cell function and cytokine signaling pathways.

Product Title:PE Anti-Mouse CD122 Antibody [5H4]
SKU:AGEL0792
Size:50 Tests, 100 Tests, 200 Tests
Clone No:5H4
Synonyms:Interleukin-2 receptor subunit beta;Il2rb;IL-2 receptor subunit beta; IL-2R subunit beta;IL-2RB;High affinity IL-2 receptor subunit beta;p70-75;CD122;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P16297
Gene ID:16185
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

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