FITC Anti-Mouse CD122 Antibody [5H4] (AGEL0791)

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SKU:
AGEL0791
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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FITC Anti-Mouse CD122 Antibody [5H4]

The Mouse CD122 Monoclonal Antibody (FITC-conjugated, 5H4-AGEL0791) offered by Assay Genie is a cutting-edge tool for researchers delving into immune responses and cell signaling cascades. This monoclonal antibody specifically targets CD122, a crucial protein involved in the activation and function of immune cells, particularly in the context of interleukin-2 (IL-2) signaling pathways.Derived from mouse hybridoma cells, this antibody is meticulously validated for its specificity and sensitivity in various experimental techniques. By conjugating FITC to the antibody, it allows for easy and precise detection of CD122 in flow cytometry and immunofluorescence assays. Researchers can confidently utilize this antibody to explore the expression levels and localization of CD122 in different cell types, shedding light on its role in immune regulation and potential therapeutic targeting.

CD122, also known as the IL-2 receptor beta chain, is integral to T cell activation, proliferation, and survival, making it a focal point in immunology research. Understanding the dynamics of CD122 expression and engagement with IL-2 is paramount in unraveling immune responses in health and disease, including autoimmune disorders and cancer. By employing the Mouse CD122 Monoclonal Antibody (FITC-conjugated, 5H4-AGEL0791), researchers can delve deeper into the complexities of immune signaling pathways and potentially identify new avenues for therapeutic interventions.

Product Title:FITC Anti-Mouse CD122 Antibody [5H4]
SKU:AGEL0791
Size:50 Tests, 100 Tests, 200 Tests
Clone No:5H4
Synonyms:Interleukin-2 receptor subunit beta;Il2rb;IL-2 receptor subunit beta; IL-2R subunit beta;IL-2RB;High affinity IL-2 receptor subunit beta;p70-75;CD122;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:FITC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:FITC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P16297
Gene ID:16185
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

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