Biotin Anti-Mouse CD122 Antibody [5H4] (AGEL0145)

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SKU:
AGEL0145
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
5H4
Conjugation:
Biotin
Applications:
FC
Frequently bought together:

Description

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Biotin Anti-Mouse CD122 Antibody [5H4]

The Mouse CD122 Monoclonal Antibody (Biotin Conjugated, 5H4, AGEL0145) is a specialized tool designed for research applications involving CD122, a key protein involved in immune responses and cell signaling pathways. This monoclonal antibody, produced for mouse samples, offers high specificity and sensitivity in detecting the CD122 protein, enabling precise analysis in various experimental setups.CD122, also known as the interleukin-2 receptor subunit beta, plays a pivotal role in the immune system by mediating responses to interleukin-2 (IL-2), a critical cytokine involved in T cell activation and proliferation. Understanding the expression and function of CD122 is crucial in elucidating immune response mechanisms, particularly in studies related to autoimmune diseases, immunotherapy, and infectious diseases.

The biotin-conjugated format of this antibody allows for convenient detection using streptavidin-based detection systems, offering flexibility in experimental setups such as flow cytometry, immunohistochemistry, and other immunoassays. Its high quality and reliability make it an excellent choice for researchers in immunology, oncology, and other fields exploring the intricacies of immune regulation and cell signaling pathways.

Product Title:Biotin Anti-Mouse CD122 Antibody [5H4]
SKU:AGEL0145
Size:25µg, 100µg
Clone No:5H4
Synonyms:Interleukin-2 receptor subunit beta;Il2rb;IL-2 receptor subunit beta; IL-2R subunit beta;IL-2RB;High affinity IL-2 receptor subunit beta;p70-75;CD122;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Biotin Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Biotin
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P16297
Gene ID:16185
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

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