GenieFluor 488 Anti-Mouse CD122 Antibody [5H4] (AGEL0146)

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SKU:
AGEL0146
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a
Clone:
5H4
Conjugation:
AF 488
Applications:
FC
Frequently bought together:

Description

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GenieFluor 488 Anti-Mouse CD122 Antibody [5H4]

The Mouse CD122 Monoclonal Antibody (ALEXA FLUOR 488 Conjugated 5H4, AGEL0146) offered by Assay Genie is a cutting-edge tool for research involving CD122, a key cell surface receptor that plays a vital role in immune cell function. This antibody, derived from mouse monoclonal sources and conjugated with ALEXA FLUOR 488 for enhanced detection capabilities, is specifically designed for use in flow cytometry applications. Its high specificity and sensitivity make it an invaluable asset for studying immune cell populations and understanding the role of CD122 in immune responses.CD122, also known as the Interleukin-2 receptor beta chain, is a crucial component in the signaling pathway that regulates the proliferation and activation of immune cells. By targeting CD122 with this monoclonal antibody, researchers can delve into the mechanisms underlying immune cell activation, differentiation, and survival.

This insight is pivotal for advancing our knowledge of immune function and developing novel therapeutic strategies for immune-related diseases such as autoimmune disorders, infectious diseases, and cancer.Utilizing the Mouse CD122 Monoclonal Antibody (ALEXA FLUOR 488 Conjugated 5H4, AGEL0146) from Assay Genie opens up new avenues for exploring the intricate workings of the immune system and unlocking potential opportunities for therapeutic intervention. Its precise targeting and reliable performance make it an indispensable tool for researchers in the fields of immunology, oncology, and beyond.

Product Title:GenieFluor 488 Anti-Mouse CD122 Antibody [5H4]
SKU:AGEL0146
Size:50 Tests, 100 Tests, 200 Tests
Clone No:5H4
Synonyms:Interleukin-2 receptor subunit beta;Il2rb;IL-2 receptor subunit beta; IL-2R subunit beta;IL-2RB;High affinity IL-2 receptor subunit beta;p70-75;CD122;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:Genie Fluor 488 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:Genie Fluor488
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P16297
Gene ID:16185
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

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