APC Anti-Mouse CD119 Antibody [GR-20] (AGEL1440)

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SKU:
AGEL1440
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FC
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG2a,k
Clone:
GR-20
Conjugation:
APC
Frequently bought together:

Description

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APC Anti-Mouse CD119 Antibody [GR-20]

The Mouse CD119 Monoclonal Antibody (APC-conjugated) GR-20 (AGEL1440) is a highly specific antibody designed for research applications involving CD119, also known as the Interleukin-1 receptor type 1 (IL-1R1). This monoclonal antibody, produced using hybridoma technology, is conjugated with APC for easy detection and analysis in flow cytometry and other assays. It is particularly valuable for studies focusing on the IL-1 signaling pathway and its impact on inflammatory responses.CD119, a key receptor for the pro-inflammatory cytokine interleukin-1, plays a pivotal role in regulating immune and inflammatory processes. By targeting CD119 with this monoclonal antibody, researchers can investigate its role in various cellular functions, such as cytokine production, immune cell activation, and inflammatory signaling pathways.

This antibody's specificity and sensitivity make it an essential tool for studying immune responses, inflammation-related disorders, and potential therapeutic interventions targeting the IL-1 pathway.With its high affinity and specificity for CD119, the Mouse CD119 Monoclonal Antibody (APC-conjugated) GR-20 (AGEL1440) offers researchers a reliable tool for in-depth exploration of IL-1R1 biology and its implications in immunology and inflammation research. Whether examining immune cell populations, cytokine responses, or inflammatory signaling cascades, this antibody provides precise detection capabilities to advance understanding of immune regulation and disease mechanisms mediated by the IL-1 receptor.

Product Title:APC Anti-Mouse CD119 Antibody [GR-20]
SKU:AGEL1440
Size:25µg, 100µg
Clone No:GR-20
Synonyms:Interferon gamma receptor 1;Ifngr1;IFN-gamma-R1;IFN-gamma-R-alpha;CD119;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P15261
Gene ID:15979
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CDw119 is a 90 kD immunoglobulin superfamily member, also known as IFN-γRα chain. It is a class II cytokine receptor family member that serves as a IFN-γ-binding chain associated with the IFN-γ β chain also known as AF-1. In addition to ligand binding, CDw119 participates in ligand trafficking. CDw119 is expressed on T and B cells, NK cells, fibroblasts, endothelial, and epithelial cells. Binding of IFN-γ induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-γ initiates and regulates a variety of immune responses.

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