PE Anti-Mouse CD115 Antibody [AFS98] (AGEL1366)

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SKU:
AGEL1366
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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PE Anti-Mouse CD115 Antibody [AFS98]

The Mouse CD115 Monoclonal Antibody PE Conjugated (AFS98) is a versatile tool for researchers studying the CD115 protein, a cell surface receptor known to be involved in the differentiation and function of monocytes and macrophages. This antibody, conjugated to phycoerythrin (PE), is specifically designed for flow cytometry applications, allowing for the precise identification and analysis of CD115-expressing cells in samples.CD115, also known as colony-stimulating factor 1 receptor (CSF-1R), plays a crucial role in the proliferation, survival, and differentiation of mononuclear phagocytes, making it a key player in the immune response and inflammation regulation. By targeting CD115 with this monoclonal antibody, researchers can gain insights into the dynamics of monocyte and macrophage populations in various tissues and disease states, including cancer, infectious diseases, and autoimmune disorders.

The PE-conjugated AFS98 monoclonal antibody offers high sensitivity and specificity in detecting CD115, enabling accurate quantification and characterization of CD115-expressing cells. Its validated performance in flow cytometry makes it an invaluable tool for immunologists, oncologists, and researchers exploring the role of monocytes and macrophages in health and disease. Unlock the potential of CD115 research with this reliable and efficient antibody for flow cytometry analysis.

Product Title:PE Anti-Mouse CD115 Antibody [AFS98]
SKU:AGEL1366
Size:50 Tests, 100 Tests, 200 Tests
Clone No:AFS98
Synonyms:Macrophage colony-stimulating factor 1 receptor;CSF-1 receptor (EC:2.7.10.1);CSF-1-R;CSF-1R;M-CSF-R;Proto-oncogene c-Fms;CD115;Csf1r;Csfmr;Fms;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P09581
Gene ID:12978
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.

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