APC Anti-Mouse CD115 Antibody [AFS98] (AGEL1369)

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SKU:
AGEL1369
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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APC Anti-Mouse CD115 Antibody [AFS98]

The Mouse CD115 Monoclonal Antibody (APC-Conjugated) is a vital tool for research involving CD115, a cell surface molecule known to be a receptor for macrophage colony-stimulating factor (M-CSF). This antibody, designated as AFS98 (AGEL1369), has been specifically developed to detect and analyze CD115 in various biological samples. CD115, also referred to as CSF-1 receptor, plays a crucial role in the regulation of macrophage differentiation and function. By targeting this receptor, researchers can gain valuable insights into immune responses, inflammatory processes, and the development of macrophages.

The APC conjugation allows for fluorescent detection of the antibody in flow cytometry experiments, enabling precise analysis of cell populations expressing CD115.This antibody is particularly valuable for studies in immunology, oncology, and inflammatory diseases where the role of macrophages and their differentiation is of interest. Its specificity and reliability in binding to CD115 make it a trusted tool for researchers investigating the intricate mechanisms of immune regulation and the potential therapeutic applications in related disorders.

Product Title:APC Anti-Mouse CD115 Antibody [AFS98]
SKU:AGEL1369
Size:25µg, 100µg
Clone No:AFS98
Synonyms:Macrophage colony-stimulating factor 1 receptor;CSF-1 receptor (EC:2.7.10.1);CSF-1-R;CSF-1R;M-CSF-R;Proto-oncogene c-Fms;CD115;Csf1r;Csfmr;Fms;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P09581
Gene ID:12978
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.

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